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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; <t>LepR,</t> soluble <t>leptin</t> receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.
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<t>Leptin</t> receptor (Ob-R) antagonist reduced the number of metastatic lung nodules and the diameter of nodules. (A) Procedure of animal experiment. Nude mice received venous transplantation of TPC-1 cells. To block OB-R, 1 mg/kg of Allo-aca was administrated to the animal per day. (B) Gross morphology of mice lungs showed nodules. Allo-aca reduced the number of pulmonary nodules. (C) Lung nodules were diagnosed as metastatic tumour under the light microscope. Allo-aca reduced the diameter of the nodules. (D) The lung nodules were examined by Western blot of thyroglobulin (TG). The nodules in the lungs were TG -positive, while the lung tissue was TG -negative. This result confirmed that the lung nodules were from thyroid carcinoma. (E–H) Allo-aca increased the level of serum T3, and had no significant effect on the level of T4, TSH and the body weight of the animal. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001, ns: not statistically significant.
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Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; LepR, soluble leptin receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.

Journal: PLOS One

Article Title: Metabolomics and glucose tolerance in pregnancy and postpartum: The PONCH study

doi: 10.1371/journal.pone.0335708

Figure Lengend Snippet: Selected clinical measurements (A) and metabolites (B) are compared between NW (n = 33), OB (n = 32), GDM-NW (n = 15) and GDM-OB (n = 16) women. The boxes represent the 25 th to 75 th percentiles with Tukey whiskers and the line indicating median. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 for group comparisons using Kruskal-Wallis analysis and Mann-Whitney-U statistics adjusted for multiple comparisons. Observed power for Kruskal-Wallis analysis was ≥ 0.8 for all variables except one (Valine, power = 0.4) C) Overview of significant differences. NW, women of normal weight; OB, women with obesity; GDM-NW, women with GDM and of normal weight; GDM-OB, women with GDM and obesity; LepR, soluble leptin receptor; HOMA-IR, homeostatic model assessment of insulin resistance; BCAA, branched chained amino acids.

Article Snippet: Leptin (Human Leptin Quantikine, R&D Systems, Minneapolis, MN; interassay coefficient of variation, 8.0% at 9 μg/l), the soluble leptin receptor (LepR) (Human Leptin R Quantikine, R&D Systems) and adiponectin (Human Adiponectin ELISA kit, Millipore, Billerica, MA; interassay coefficient of variation, 7.0% at 10.5 mg/l) were analysed simultaneously for all samples using ELISA.

Techniques: MANN-WHITNEY

Leptin receptor (Ob-R) antagonist reduced the number of metastatic lung nodules and the diameter of nodules. (A) Procedure of animal experiment. Nude mice received venous transplantation of TPC-1 cells. To block OB-R, 1 mg/kg of Allo-aca was administrated to the animal per day. (B) Gross morphology of mice lungs showed nodules. Allo-aca reduced the number of pulmonary nodules. (C) Lung nodules were diagnosed as metastatic tumour under the light microscope. Allo-aca reduced the diameter of the nodules. (D) The lung nodules were examined by Western blot of thyroglobulin (TG). The nodules in the lungs were TG -positive, while the lung tissue was TG -negative. This result confirmed that the lung nodules were from thyroid carcinoma. (E–H) Allo-aca increased the level of serum T3, and had no significant effect on the level of T4, TSH and the body weight of the animal. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001, ns: not statistically significant.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: Leptin receptor (Ob-R) antagonist reduced the number of metastatic lung nodules and the diameter of nodules. (A) Procedure of animal experiment. Nude mice received venous transplantation of TPC-1 cells. To block OB-R, 1 mg/kg of Allo-aca was administrated to the animal per day. (B) Gross morphology of mice lungs showed nodules. Allo-aca reduced the number of pulmonary nodules. (C) Lung nodules were diagnosed as metastatic tumour under the light microscope. Allo-aca reduced the diameter of the nodules. (D) The lung nodules were examined by Western blot of thyroglobulin (TG). The nodules in the lungs were TG -positive, while the lung tissue was TG -negative. This result confirmed that the lung nodules were from thyroid carcinoma. (E–H) Allo-aca increased the level of serum T3, and had no significant effect on the level of T4, TSH and the body weight of the animal. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001, ns: not statistically significant.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: Transplantation Assay, Blocking Assay, Light Microscopy, Western Blot, Standard Deviation

The conditioned medium of ADSCs upregulated the level of leptin receptor (Ob-R) in TPC-1 and BCPAP cells. (A) The concentration of leptin in the medium of ADSCs was ∼3-fold higher than that in the medium of TPC-1 and BCPAP cells, approximately 50 pg/ml. (B) In vitro experiments showed that ADSC-CM increased the level of leptin receptor (Ob-R) in the TPC-1/BCPAP cells. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: The conditioned medium of ADSCs upregulated the level of leptin receptor (Ob-R) in TPC-1 and BCPAP cells. (A) The concentration of leptin in the medium of ADSCs was ∼3-fold higher than that in the medium of TPC-1 and BCPAP cells, approximately 50 pg/ml. (B) In vitro experiments showed that ADSC-CM increased the level of leptin receptor (Ob-R) in the TPC-1/BCPAP cells. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: Concentration Assay, In Vitro, Standard Deviation

The neutralizing antibody to leptin reduced the invasion and migration of the TPC-1 and BCPAP cells. ADSC-CM upregulated MMP-2 in TPC-1 and BCPAP cells, and the effect was attenuated by the neutralizing antibody to leptin. (A) Addition of 10 μg/mL NAB of leptin to ADSC-CM conditioned medium attenuated TPC-1 and BCPAP invasion. (B) Leptin NAB also attenuated conditioned medium-promoted TPC-1/BCPAP migration. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: The neutralizing antibody to leptin reduced the invasion and migration of the TPC-1 and BCPAP cells. ADSC-CM upregulated MMP-2 in TPC-1 and BCPAP cells, and the effect was attenuated by the neutralizing antibody to leptin. (A) Addition of 10 μg/mL NAB of leptin to ADSC-CM conditioned medium attenuated TPC-1 and BCPAP invasion. (B) Leptin NAB also attenuated conditioned medium-promoted TPC-1/BCPAP migration. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, *** p < 0.001.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: Migration, Standard Deviation

Neutralizing antibodies against leptin slightly downregulated cell proliferation without significant effect on cell viability. (A) Addition of leptin NAB to ADSC-CM slightly reduced the stimulatory effect of conditioned medium on TPC-1 proliferation. (B) Addition of NAB to the conditioned medium had no significant effect on cell viability of TPC-1 cells. (C) NAB of leptin had no significant effect on BCPAP proliferation. (D) NAB of leptin had no significant effect on BCPAP viability. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, ns: not statistically significant.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: Neutralizing antibodies against leptin slightly downregulated cell proliferation without significant effect on cell viability. (A) Addition of leptin NAB to ADSC-CM slightly reduced the stimulatory effect of conditioned medium on TPC-1 proliferation. (B) Addition of NAB to the conditioned medium had no significant effect on cell viability of TPC-1 cells. (C) NAB of leptin had no significant effect on BCPAP proliferation. (D) NAB of leptin had no significant effect on BCPAP viability. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, ns: not statistically significant.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: Standard Deviation

(A,B) The ADSCs conditioned medium upregulated the MMP-2 levels of TPC-1/BCPAP. NAB of leptin partially counteracted the increase in MMP-2 levels. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, ** p < 0.01.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: (A,B) The ADSCs conditioned medium upregulated the MMP-2 levels of TPC-1/BCPAP. NAB of leptin partially counteracted the increase in MMP-2 levels. Experiments were repeated at least five times. Data are expressed as mean ± standard deviation. * p < 0.05, ** p < 0.01.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: Standard Deviation

Hypothesis diagram. Adipose tissue acts on thyroid cancer cells by secreting leptin. Leptin upregulates the level of the leptin receptor (Ob-R) on the surface of thyroid cancer cells and up-modulates the level of MMP-2 by activating the leptin signalling pathway, which may be an important mechanism by which obesity promotes the metastasis of thyroid cancer cells.

Journal: Annals of Medicine

Article Title: Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway

doi: 10.1080/07853890.2024.2419990

Figure Lengend Snippet: Hypothesis diagram. Adipose tissue acts on thyroid cancer cells by secreting leptin. Leptin upregulates the level of the leptin receptor (Ob-R) on the surface of thyroid cancer cells and up-modulates the level of MMP-2 by activating the leptin signalling pathway, which may be an important mechanism by which obesity promotes the metastasis of thyroid cancer cells.

Article Snippet: The PVDF membranes were blocked with BSA (Sigma-Aldrich) and then hybridized with antibodies, including the following: mouse monoclonal IgG of leptin receptor (Ob-R) antibody (R&D Systems, catalog# MAB867, diluted 1:500), rabbit polyclonal MMP-2 (Cell Signaling Technology, catalog# 4022, diluted 1:1000), MMP-9 antibodies (Signaling Technology, catalog# 3852, diluted 1:1000), rabbit monoclonal thyroglobulin antibody (Abcam, catalog# ab243094, diluted 1:1000), rabbit polyclonal GAPDH antibody (Abcam, catalog# ab9485, diluted 1:1000), goat anti-mouse IgG (Abcam, catalog# ab6789, diluted 1:2000), goat anti-rabbit IgG (Abcam, catalog# ab205718, diluted 1:2000).

Techniques: